Sudden rest in dialysis patients iron

This article shows iron stores cause rest by heart attack ..

A value of 74 ms has been buttociated with risk for serious arrhythmias related to sudden rest in dialysis patients. A linear relationship showed that at 74 ms of QTc dispersion, TSAT was 35.2%

Am J Kidney Dis. 2004 Oct;44(4):720-8. Related Articles, Links

The effect of iron stores on corrected QT dispersion in patients undergoing peritoneal dialysis.

Wu VC, Huang JW, Wu MS, Chin CY, Chiang FT, Liu YB, Wu KD.

Department of Internal Medicine, Far Eastern Memory Hospital, Taipei, Taiwan.

BACKGROUND: Arrhythmia and sudden rest represent striking features in patients with end-stage renal disease (ESRD). Increased QT dispersion has been shown to be buttociated with arrhythmias. Abnormal excitability and heterogeneous cardiac iron deposition may cause the arrhythmogenesis of human siderotic heart disease. Iron overload and precipitation with its toxicity in cardiac muscles may, therefore, cause QT prolongation in dialysis patients. METHODS: A total of 102 (65 women, 37 men; mean age, 47.7 +-- 13.4 years) nondiabetic patients undergoing peritoneal dialysis (PD) were enrolled in this study. Another 102 subjects with a serum creatinine level less than 1.5 mg-dL (133 micromol-L) were used as matched control subjects. The PD patients were divided into 2 groups according to whether their computerized measurements of corrected QT (QTc) dispersion were longer than 74 ms. A value of 74 ms has been buttociated with risk for serious arrhythmias related to sudden rest in dialysis patients. RESULTS: The QTc dispersion of PD patients was significantly longer than that Thirty-eight PD patients with QTc dispersion longer than 74 ms had lower blood pressure ( P = 0.01), fewer left ventricle mbuttes ( P = 0.036), and lower serum albumin levels (P = 0.046) but higher levels of serum calcium (P = 0.038) and transferrin saturation (TSAT; P = 0.022) than the other patients. Multivariate analysis identified TSAT as an independent factor for QTc dispersion (r = dispersion, TSAT was 35.2%. CONCLUSION: Long-term PD patients have longer QTc dispersion than subjects with normal renal function. The high body iron stores in these patients increase the risk of increased QT dispersion. The concern over iron overload in dialysis patients is not only because of its oxidative toxicity, but also its precipitation of arrhythmias, which may be measured by the surrogate marker of QTc dispersion.

PMID: 15384024 PubMed - in process

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